Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia

C-terminal polymorphism of Plasmodium falciparium merozoite surface protein-1 (MSP-1) from Tak Province, Thailand.

This study was undertaken to ascertain the extent of polymorphism in the C-terminal region of Plasmodium falciparum merozoite surface protein (MSP-1) from 119 malaria patients in Tak Province on the western border of Thailand, who were admitted to the Bangkok Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. P. falciparum infection was confirme...

Genetic Diversity and Natural Selection in 42 kDa Region of Plasmodium vivax Merozoite Surface Protein-1 from China-Myanmar Endemic Border

Plasmodium vivax merozoite surface protein-1 (PvMSP1) gene codes for a major malaria vaccine candidate antigen. However, its polymorphic nature represents an obstacle to the design of a protective vaccine. In this study, we analyzed the genetic polymorphism and natural selection of the C-terminal 42 kDa fragment within PvMSP1 gene (Pv MSP142) from 77 P. vivax isolates, collected from imported c...

ficolin-a enhances inhibition of the c-terminal 19 kda region of merozoite surface protein-1 of plasmodium berghei using test in vivo.

background : malaria remains a serious public health problem with significant morbidity and mortal-ity. this study was conducted to identify whether ficolin-a could play an active role of against mala-ria infection. methods : the function of ficolin-a was analyzed in mouse model. the open reading frame of fico-lin-a was cloned from the liver of new born c57bl/6 mice by rt-pcr and then inserted ...

Genetic Diversity Block 2 of Surface Protein-1 in Plasmodium Falciparum Merozoite by Nested-PCR Method in Southeastern Iran

Abstract       Background and Objectives: Plasmodium falciparum merozoite surface protein-1 (PfMSP-1) is a promising vaccine against malaria during its blood stages which play an important role in immunity to this disease. Polymorphic nature of this gene is a major obstacle in making an effective vaccine against malaria. In this study, the genetic diversity of Plasmodi...

Parasite-Specific Antibodies Protein-1-Specific Antibodies but Not Whole Region of Merozoite Surface Maternally Derived 19-kDa C-Terminal Antibody Responses in Neonatal Pups by Merozoite Surface Protein-1-Specific Inhibition of 19-kDa C-Terminal Region of